Serratiopeptidase Information
Serratiopeptidase, an enzyme
isolated from a microorganism in silkworm, is widely used in clinical practice
in Japan. Until more is known about the long term benefit and side effects of
serratiopeptidase, we recommend limiting daily dose to 20,000 units.
SerratioPeptidase
Enteric Coated - pH Resistant
Fhysician Formulas
Developed by
Ray Sahelian, M.D.
Manufactured by a FDA approved and GMP certified facility.
The silkworm has
serrapeptase (also known as Serratio Peptidase or serratiopeptidase),
a proteolytic enzyme. This enteric coated
serratiopeptidase
product by Physician
Formulas is of the highest quality available. It is
manufactured by a FDA approved facility. You can be sure you are getting exactly
what you pay for.
Serratiopeptidase, isolated from the microorganism Serratia E15,
is
naturally present in the silkworm intestine which allows the emerging moth to
dissolve its cocoon. Clinical use of
serratiopeptidase
in Europe and Asia spans over
twenty five years.
Serrapeptase Supplement Facts
Serrapeptase - 200mg*
SerratioPeptidase
(20,000 units enteric coated granules - 120,000
units per gram)
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* Serratiopeptidase daily value not established.
Serratiopeptidase
summary
Serratiopeptidase
appears to be a supplement with some clinical potential,
however much more research is needed before we determine what clinical role this
enzyme has in medicine. In the meantime, only use
serratiopeptidase
under medical
supervision until more studies determine the full spectrum of
serratiopeptidase
side
effects and benefits.
Conditions where serratiopeptidase has been studied
Chronic airway lung disease
Chronic ear, nose or throat disorders
Carpal tunnel syndrome
Serratiopeptidase has even been studied in certain cases of edema after an operation
or injury.
Serratiopeptidase Research Update
Effect of the proteolytic enzyme serratiopeptidase in patients with chronic airway
disease.
Respirology. 2003 Sep;8(3):316-20.
The proteolytic enzyme serratiopeptidase is widely used in clinical
practice in Japan. We investigated the effect of serrapeptase on sputum properties and
symptoms in patients with chronic airway diseases. This study was an
open-labeled trial with a non-treatment control group. Patients were randomly
assigned to oral treatment and without serratiopeptidase 30 mg/day for
4 weeks. Patients collected sputum samples for about 4 hours in the morning on the
day the trial began and 4 weeks later. Part of each sputum sample was weighed and then completely dried and
reweighed. The percentage solid component, viscosity and elasticity of the
sputum were measured. Mucociliary transportability index was measured using
ciliated bovine trachea ex vivo. After 4 weeks of serratiopeptidase treatment, sputum
weight in the morning, percentage solid component, viscosity and elasticity of
sputum, sputum neutrophil count, frequency of coughing and frequency of
expectoration significantly decreased. CONCLUSIONS: serratiopeptidase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers
and altering the viscoelasticity of sputum in patients with chronic airway
diseases.
A preliminary trial of serratiopeptidase in patients with carpal tunnel
syndrome.
J Assoc Physicians India. 1999 Dec;47(12):1170-2.
This study was planned to assess the response of serratiopeptidase in
patients with carpal tunnel syndrome (CTS). Twenty patients with CTS were
evaluated clinically. After baseline electrophysiological studies, these
patients were given serrapeptase 10 mg twice daily with initial short
course of nimesulide. Clinical and electrophysiological reassessment was done
after 6 weeks. Sixty five percent of
serratiopeptidase
cases showed significant clinical
improvement which was supported by improvement in
electrophysiological parameters. Recurrence was reported in four cases. No
significant side effect was observed. CONCLUSIONS:
serratiopeptidase
therapy may
proved to be a useful alternative mode of conservative treatment. Larger study
may be further helpful to establish the role of
serratiopeptidase
in CTS.
Serratiopeptidase therapy.
Q. I have been looking into the use of
serratiopeptidase
during my pregnancy to help with some varicose veins that
have developed. My midwives said it is a completely natural product, but they
see no studies supporting the safety of its use during pregnancy. Do you have
any information regarding this, or could you direct me?
A. We have not seen any studies regarding the safety of
serratiopeptidase during pregnancy.
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