Resveratrol pill - What is the right dosage? Will taking these pills help you live longer? Are the anti-aging claims true?

Have you heard the hype about resveratrol pills helping mice live longer? It seems this red wine ingredient is now the rage and consumers are flocking to vitamin stores or on the internet to buy a resveratrol pill. Before you rush to make a purchase, do yourself a favor by getting a balanced viewpoint on this topic. There are a number of other supplements that have become more popular, including mangosteen plant, Goji berry, noni fruit, and acai berry.
   As of 2011, there have not been any long term human studies with resveratrol supplements to determine whether the promising findings in animal studies will be replicated when men and women take this dietary supplement daily for weeks, months and years.

Resveratrol pill 10 mg per capsule

Resveratrol ( trans-3,5,4'-trihydroxystilbene ) is a protective compound produced by grapes and other plants in response to environmental stresses. Studies have demonstrated that it has potent antioxidant activity and also has the ability to inhibit platelet aggregation. These actions may help prevent free radical damage throughout the body and provide protective support to the cardiovascular system.

Resveratrol pill 10 mg
buy resveratrol supplement.


What is it?
Resveratrol is a protective compound produced by grapes, berries, and other plants in response to environmental stresses. A high concentration is found in red wine, particularly Pinot Noir.

The Hype
What made it popular was a 2006 study published by Harvard University researchers in Boston that reported mice lived longer when given a resveratrol supplement. The news media caught up with titles such as, "Resveratrol improves health and survival of mice on a high-calorie diet.”

How much resveratrol is there in red wine?
Red wine has about 1.5 to 3 milligrams per liter (a liter is almost 34 ounces).

Benefits of resveratrol pill
Resveratrol has potent antioxidant activity and also has the ability to inhibit platelet aggregation thus making the blood less likely to clot. In addition, it has anti-inflammatory, anti-tumor, and anti-infective properties. Resveratrol may even by helpful in preventing neuronal damage in Alzheimer’s disease.

Blood vessels
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
Am J Physiol Heart Circ Physiol. 2010. Ungvari ZI, Bagi Z, Feher A, Sonntag WE, Pearson KJ, de Cabo R, Csiszar A. University of Oklahoma.
Epidemiological studies suggest that Mediterranean diets rich in resveratrol are associated with reduced risk of coronary artery disease. Resveratrol was also shown to confer vasoprotection in animal models of type 2 diabetes and aging. However, the mechanisms by which resveratrol exerts its anti-oxidative vasculoprotective effects are not completely understood. Using a Nrf2/ARE-driven luciferase reporter gene assay we found that in cultured coronary arterial endothelial cells resveratrol, in a dose dependent manner, significantly increases transcriptional activity of Nrf2. Accordingly, resveratrol significantly up-regulates the expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1, gamma-glutamylcysteine synthetase and heme oxygenase-1. Resveratrol treatment also significantly attenuated high glucose (30 mM) -induced mitochondrial and cellular oxidative stress (assessed by flow cytometry using MitoSox and DHE staining).

Resveratrol pill and Longevity
Harvard researchers tested resveratrol on middle aged mice. Supplementation increased their survival. In previous studies over the past few years, resveratrol was found to have a similar longevity benefit on yeast, flies and worms. This was the first evaluation of resveratrol on survival extension in mammals. One group of mice ate a normal diet. The second was fed a high-calorie diet and the third had the same high calorie diet but was given resveratrol supplements. By the time the mice were 114 weeks old, about 60 percent in the high-calorie group had died, compared to about 40 percent in the low calorie diet group and the group with the high calorie diet supplemented with resveratrol. The mice taking resveratrol had healthier heart and liver tissue, decreased blood sugar levels, better insulin sensitivity and were more active than the other rodents.

Resveratrol and cancer
Recent laboratory studies indicate that resveratrol has potential in various cancers, including breast, prostate, and neuroblastoma.

Resveratrol side effects, is it safe? Any danger?
Since human studies are not available, we don’t know the long term side effects of daily use.

Availability and dosage
Much of the resveratrol pills sold in supplement form are from the herb Polygonum cuspidatum. The most common dosage is 10 mg of resveratrol per capsule or tablet. No one knows at this time the ideal dosage of resveratrol to take on a daily basis and how it would interact with other supplements or medicines. We can only tell you that we plan to take one 10 mg capsule once or twice a week until more research is available, and we also plan to drink one or two ounces of red wine most evenings with dinner.

questions
Q. Does resveratrol pill use lead to weight loss?
   A. We have not seen any human studies regarding resveratrol and loss of weight. Hoodia can work well in some people.

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