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Maca herb information, studies, review and use for fertility and sexual benefits - Maca extract helps restore sexual health to those on SSRI drugs such as Prozac, Paxil, and Zoloft
Maca (Lepidium meyenii) is a root-like vegetable
shaped like a radish. It grows in the harsh climate of the Andes Mountains in
South America at elevations from 11,000 to
up to 15,000 feet. Maca is traditionally used in the Andean region for its
supposed aphrodisiac and fertility-enhancing properties.
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What Maca extract research
says
In one study, researchers fed high dosages of maca extracts to male
mice. As a result, the
frequency with which they coupled with female mice
tripled. In rats with erectile
dysfunction, the time needed between successive
couplings was reduced by half.
Maca prevents prostate
enlargement in mice
Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in
adult mice.
Andrologia. 2008 Jun;40(3): Gonzales GF, Gasco M, Malheiros-Pereira A,
Gonzales-Castañeda C. Gonzales GF, Gasco M, Malheiros-Pereira A, Gonzales-Castañeda
C. Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura,
Universidad Peruana Cayetano Heredia, Lima, Peru.
The present study was designed to determine the effect of red maca in the
prostate hyperplasia induced with testosterone enanthate in adult mice. Our
results show maca has an anti-hyperplastic effect on the prostate of adult mice
when hyperplasia was induced with testosterone acting first at prostatic stromal
level.
Maca Research
studies
The in vitro biological activity of Lepidium meyenii maca extracts.
Cell Biol Toxicol. 2006 Mar;22(2):91-9.
Valentova K, Buckiova D, Kren V, Peknicova J, Ulrichova J, Simanek V.
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky
University, Olomouc.
The biological activity of methanolic and aqueous extracts from dehydrated
hypocotyls of Lepidium meyenii (Brassicaceae, vernacular name maca ), was
studied on rat hepatocytes and human breast cancer MCF-7 cells. The maca
extracts did not exhibit cytotoxicity in hepatocyte primary cultures up to 10
mg/ml as measured by the MTT viability test, and lactate dehydrogenase (LDH) and
aspartate aminotransferase (AST) leakage. Moreover, after 72 h, extracts
inhibited LDH and AST leakage from the hepatocytes. When hepatocytes were
intoxicated by t-butyl hydroperoxide, neither extract prevented oxidative
damage. Both maca extracts showed weak antioxidant activity in the DPPH radical
scavenging test with IC(50) values of 3.46 +/- 0.16 and 0.71 +/- 0.10 mg/ml, for
aqueous and methanolic extracts, respectively. Thus, the observed effect on
spontaneous enzyme leakage is probably mediated through mechanisms other than
antioxidant activity. Both methanolic and aqueous maca extracts have shown
estrogenic activity comparable with that of silymarin in MCF-7 cell line. Maca
estrogenicity was exhibited in the range from 100 to 200 mug of extract per ml.
The findings in the present study show that maca does not display in vitro
hepatotoxicity. In contrast, a slight cytoprotective effect, probably not
mediated by antioxidant capacity, was noted. Maca extracts exhibited estrogenic
activity comparably to the effect of silymarin in MCF-7 cells.
Maca reversed the
lead acetate induced-Damage on reproductive function in male rats.
Food Chem Toxicol. 2006 Feb 27;
Rubio J, Riqueros MI, Gasco M, Yucra S, Miranda S, Gonzales GF.
Department of Biological and Physiological Sciences, Faculty of Sciences and
Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru; Instituto de
Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
Rats were treated with 0, 8, 16 and 24mg/kg of lead acetate (LA) (i.p.) for 35
days with or without Maca. Maca was co-administrated orally from day 18 to day
35. The lengths of stages of the seminiferous epithelium were assessed by
transillumination. Also, sex organ weights, testicular and epididymal sperm
count, sperm motility, daily sperm production, sperm transit rate and serum
testosterone levels were measured. Lead acetate treatment resulted in a
dose-response reduction of lengths of stages VIII and IX-XI, and serum
testosterone levels. However, rats treated with 8 and 16mg/kg but not 24mg/kg of
lead acetate showed a low number of testicular spermatids, low daily sperm
production (DSP) and low epididymal sperm count. Administration of Maca to rats
treated with lead acetate resulted in higher lengths of stages VIII and IX-XI
with respect to lead acetate-treated rats. Moreover, treatment with Maca to lead
acetate-treated rats resulted in lengths of stages VIII and IX-XI similar to the
control group. Maca administration also reduced the deleterious effect on DSP
caused by lead acetate treatment. Maca prevented LA-induced spermatogenic
disruption in rats and it may become in a potential treatment of male
infertility associated with lead exposure.
Effect of ethanol extract of Lepidium
meyenii Walp. on osteoporosis in ovariectomized rat.
J Ethnopharmacol. 2006 Apr 21;105(1-2):274-9. Zhang Y, Yu L, Ao M, Jin W.
School of Life Science & Technology, Huazhong University of Science &
Technology, 430074 Wuhan, PR China.
Maca is a cruciferous plant from the Andes of Peru. The
root of Maca is traditionally employed for its supposed properties in
aphrodisiacs and improving fertility, it also has been widely used to help
alleviate the symptoms of menopause. The purpose of this study was to evaluate
the effect of ethanol extract of Maca on postmenopausal osteoporosis in
ovariectomized rats. Female Sprague-Dawley rats were divided into four groups:
Sham-operated and ovariectomized groups were fed with equivolume of distilled
water, and the remaining ovariectomized groups were orally administrated with
ethanol extract of Maca at 0.096 and 0.24g/kg for 28 weeks. The findings derived
from the basis of bone mineral density, biomechanical, biochemical and
histopathological parameters indicated that higher dose of ethanol extract of
Maca was effective in the prevention of estrogen deficient bone loss.
Maca herb emails
Q. I've been taking maca powder every day and on some occasions every second day
and feel an incredible difference in my wellbeing as a result of this. However,
I have a cough which has come and gone over the past years and often persists
for months at a time. I can not remember if I got the cough this time before I
started talking maca or after but I have noticed that I start to develop more
phlegm after taking maca herb which becomes extremely irritating. I know that
phlegm it's self is protein based and that maca has a high degree of absorbable
protein and so I thought there may be some connection there. I only take half a
tea spoon in hot water at a time when taking maca but I still feel the effects
of plegm being produced after each time. I do not want to stop taking maca
because I feel so great when I take it but at the same time this cough is
driving me crazy. Do you think the way I am taking maca or the quantity that I'm
taking is affiliated with this problem?
A. Even though phlegm is protein based, it would not have anything
to do with protein in maca since people can eat chicken with protein and yet not
have phlegm. We have not heard of maca causing phlegm or couth, but then again
we don't know many people who have taken maca for prolonged periods. It is
always a good idea if a side effect is being suspected from an herb to take a
break from it. There are many herbs that have overlapping functions and effects.
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How does Maca root work?
Maca root contains sterols, uridine, malic
acid, macamides, and glucosinolates. Oil components include phenyl acetonitrile
and benzaldehyde. Many of the compounds in maca have an effect on the central
nervous system. The mechanism of action of maca is presently not well
understood, but probably seems to be independent of a hormonal effect since
studies show maca does not influence blood levels of hormones, for instance
testosterone. Maca has alkaloids, steroids, tannins, saponins, and cardiotonic
glycosides.
Influence of colour type and previous cultivation on
secondary metabolites in hypocotyls and leaves of maca (Lepidium meyenii Walpers).
J Sci Food Agric. 2010 Apr 15; Clément C, Diaz Grados DA, Avula B, Khan IA,
Mayer AC, Ponce Aguirre DD, Manrique I, Kreuzer M. ETH Zurich, Institute of
Plant, Animal and Agroecosystem Sciences, 8092 Zurich, Switzerland.
Maca is an Andean crop of the Brassicaceae family which is mainly known for its
fertility-enhancing properties following consumption. The hypocotyls display
various colours ranging from white to black. Each colour has different
biological effects. The aim of this study was to analyse the concentrations of
major secondary metabolites in hypocotyls and leaves of maca in a controlled
planting experiment in the Peruvian Andes at 4130 m above sea level. The effects
of colour type and of previous cultivation of the field were examined. In the
hypocotyls, the colour type effect was significant for most secondary
metabolites; exceptions were beta-sitosterol and campesterol. The lead-coloured,
yellow and violet maca hypocotyls were rich in glucosinolates, macaene and
macamides, respectively. Previous cultivation affected macaene, campesterol and
indole glucosinolate concentrations. Effects on metabolite concentrations in the
leaves were minor. Hypocotyls were richer in macaene, macamides and
glucosinolates than were leaves, and were poorer in beta-sitosterol and total
phenols. Colour type has to be considered in maca production, as colour
associates with variations in concentrations of distinct bioactive metabolites.
Leaves may be interesting for animal nutrition purposes as they contain
essentially the same secondary metabolites as the hypocotyls but in clearly
lower concentrations.