is an amino acid that has a benefit in numerous areas of human biochemistry,
including ammonia detoxification, hormone secretion, and the immune system. it is also of benefit as a precursor to
nitric oxide, a key component of endothelial-derived relaxing factor. The
endothelium is the lining inside blood vessels and l arginine supplements help
make more nitric oxide. Therefore, by making more nitric oxide, it helps to relax and
dilate blood vessels.
Nitric oxide is a messenger molecule involved in a variety of endothelium-dependent effects in the cardiovascular system. Because of the benefit of l arginine with nitric oxide production, it may potentially be useful in hypertension, preeclampsia, intermittent claudication, and erectile dysfunction.
Even though l arginine has been claimed to be useful for some of the conditions listed above, it would be premature to be overly excited. Much research needs to be done before we can be more confident about its potential. However, so far, l arginine appears to have a role to play in conditions involving blood vessel dilation. Whether the dilation is short lived or continues for an adequate period is still being evaluated. L Arginine does not appear to be helpful as a supplement taken by those who have suffered a heart attack. The limiting factor in the benefit as a supplement is that the conversion to nitric oxide may be short lived.
As to its function as an erection pill, see below. If you have an interest in it as a sexual enhancer, consider Passion Rx instead which is very effective.
L Arginine supplement 750 mg, 60 Capsules
L Arginine is a semi-essential amino acid synthesized by the body from ornithine. Among many functions, it is used by the body to produce creatine. Each arginine supplement tablet contains 750 mg.
Usage: Take 1 to 6 arginine supplement tablets daily, or as directed by your qualified health consultant.
Click here to buy L-Arginine capsule or Powder
One of the more popular supplements found in sexual enhancement products is L-arginine. What makes it interesting is that it can be metabolized to nitric oxide (NO). NO is the most powerful chemical known to dilate and engorge blood vessels in the penis and clitoris. What does the research say about the role of arginine in erectile dysfunction? If you wish to improve sexual function, consider Passion Rx
A Low dose of l arginine supplement, at 500 mg three times a day, has not been found to benefit impotence.
A double-blind, placebo-controlled study of 50 men with erectile dysfunction tested l arginine at a dose of 5 grams per day for six weeks. About a third of the participants who received it showed benefit, and that improvement was greater than the 10% improvement seen in the placebo group.
The amino acid L Arginine has been studied in combination with other nutrients as a treatment for sexual dysfunction in women. A small trial found some benefit with a combination treatment providing a daily dose of 2,500 mg of l arginine, as well as ginseng, ginkgo biloba, and damiana. In a four-week, double-blind study, 77 women with decreased libido were given either the combination product or a placebo. Those taking the l-arginine blend showed statistically greater benefit, reporting increased sexual desire in 71% of participants given the treatment. In the placebo group, 42% reported an increased libido.
A study done at the University of Texas at Austin examined l arginine benefit, combined with yohimbine, on sexual arousal in postmenopausal women. Twenty-four women participated in three sessions in which sexual responses to erotic stimuli were measured following treatment with either l-arginine glutamate (6 g) plus yohimbine (6 mg), yohimbine alone (6 mg), or a placebo, using a randomized, double-blind design. Sexual responses were measured at one hour after taking the supplements. Compared to placebo, the combined oral administration of l-arginine and yohimbine increased vaginal pulse amplitude responses to the erotic film. It is well known that yohimbine, alone, has a significant benefit on sexuality and whether l-arginine is not clear.
Mechanism of Action
Nitric oxide is converted into cGMP, which becomes the secondary messenger that causes smooth muscle relaxation, resulting in more blood going into the genital organs, which leads to erections. However, nitric oxide is quickly metabolized and any potential l arginine benefit could be short lived.
Potential L Arginine
There is some supporting evidence that l arginine benefits by reducing angina and lowering blood pressure. Research indicates supplemental l-arginine reduces pulmonary resistance and blood pressure. Supplementation benefits renal function in patients with chronic heart failure. Oral L-arginine benefits endothelial function in older healthy individuals. However, we are not convinced yet that l-arginine is a worthwhile supplement for erectile function or sexual enhancement, at least in low dosages.
Use for Heart Failure
L-arginine supplementation may benefit the physical fitness of heart failure patients by enhancing their endurance to exercise.
NAC and L arginine benefit for
high blood pressure
Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes.
Diabetes Care. 2008; Martina V, Manzato E, Berchio A, Massarenti P, Settanni F, Della Casa L, Bergamini S, Iannone A.
Department of Internal Medicine, University of Torino, Corso Dogliotti Torino, Italy.
We tested the effects of l-arginine and N-acetylcysteine (NAC) administration in increasing NO bioavailability by reducing free radical formation. A double-blind study was performed on 24 male patients with type 2 diabetes and hypertension divided into two groups of 12 patients that randomly received either an oral supplementation of placebo or NAC + arginine for 6 months. NAC + arginine treatment caused a reduction of both systolic and diastolic mean arterial blood pressure, total cholesterol, LDL cholesterol, oxidized LD, high-sensitive C-reactive protein, intracellular adhesion molecule, vascular cell adhesion molecule, nitrotyrosine, fibrinogen, and plasminogen activator inhibitor-1, and an improvement of the intima-media thickness during endothelial postischemic vasodilation. HDL cholesterol increased. NAC + arginine administration seems to be of benefit and well-tolerated antiatherogenic therapy because it improves endothelial function in hypertensive patients with type 2 diabetes by improving NO bioavailability via reduction of oxidative stress and increase of NO production.
Benefit for Sexual Enhancement
There are many potent herbs that have sexual enhancement properties. L-Arginine is not on our top ten list of aphrodisiac supplements that improve performance. We prefer the combination of herbs found in Passion Rx.
Hypertension treatment, influence on blood
Effect of oral L arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries.
Am J Cardiol. 2004.
Thirteen hypertensive patients with microvascular angina were studied before and after receiving oral L-arginine (4 weeks, 2 g, 3 times daily). L-arginine was of benefit in angina class, systolic blood pressure at rest, and quality of life. Maximal forearm blood flow, plasma L-arginine, L-arginine : asymmetric dimethyl arginine ratio, and cyclic guanylate monophosphate increased significantly after treatment. In medically treated hypertensive patients with micro-vascular angina, oral L-arginine may provide some benefit.
Evaluation of the antihypertensive effect of L-arginine
supplementation in patients with mild hypertension assessed with ambulatory
blood pressure monitoring.
Med Sci Monit. 2010; Ast J, Jablecka A, Bogdanski P. Department of Clinical Pharmacology, Karol Marcinkowski University of Medical Science, Poznan, Poland.
Arterial hypertension is one of the most important cardiovascular risk factors, featuring the unsatisfactory efficacy of current therapies. The cardiovascular disease paradigm which assumes a crucial role of the endothelial phenotype in shaping the state of the circulatory system has become increasingly dominant and endothelial dysfunction should be treated as avidly as the diseases of other organs. The most valued current anti-hypertensive therapies exert a positive influence on the endothelium due to their pleiotropic effects, but the search for new effective strategies aimed at improving endothelial function is underway. L-arginine trials are part of this quest. The few L-arginine studies in hypertension have brought inconclusive results. The aim of this study was to evaluate the anti-hypertensive efficacy and safety profile of L- arginine during four weeks of oral supplementation to healthy subjects and patients diagnosed with primary mild hypertension. The study was completed by 54 participants. Ambulatory blood pressure monitoring (ABPM) was used to allot patients to either a healthy control group (19 subjects) or the hypertensive treatment group (35 patients). Later the patients were randomized to either L-arginine (2 or 4 g three times daily or placebo. All participants underwent physical examination and had all basic lab tests and ABPM performed. Blood pressure (both systolic and diastolic) by ABPM showed statistically significant lowering after 4 weeks of L-arginine supplementation only in the subgroup of patients treated with 12 g of L-arginine daily, with a stronger hypotensive effect observed during the day. The present findings demonstrate a strong association between L-arginine supplementation and blood pressure reduction.
Q. Does l arginine benefit improve when taken as powder versus a capsule?
A. It depends on how much you plan to take. If your dose is 1 to 5 g, the capsule works. If you plan to take more than 5 grams of arginine, then the powder is more efficient.
Q. What are some foods high
A. All foods that have protein contain arginine.
Is l-arginine of benefit for a woman?
We can't think of a medical reason where a woman needs l-arginine to treat a particular health concern, except perhaps high blood pressure.
Do you think l-arginine is of benefit in body building?
We're much more impressed with creatine and protein powders for body building and to increase muscle size.