Curcumin Turmeric supplement

Curcumin Turmeric Information
Curcumin and Turmeric product information
 

Curcumin (diferuloylmethane), a component of dietary spice turmeric (Curcuma longa), has been shown in recent studies to have therapeutic potential in the treatment of cancer, diabetes, arthritis, and osteoporosis. Curcuminoids are the major substances that give the spice turmeric its yellow color. Curry powder which is extensively used in Indian cuisine, is largely made of turmeric and other spices such as coriander and fenugreek.
     The major curcuminoids are curcumin, demethoxycurcumin and bisdemethoxycurcumin which are powerful antioxidants and anti-inflammatory compounds. For more curcumin information.

Curcumin and Turmeric 500 mg, 60 capsules
Physician Formulas -- developed by Ray Sahelian, M.D.
Curcumin is one of the major antioxidants found in the spice turmeric. The roots of the turmeric plant are used as an herb in Asian cooking such as curries. Curcumin is a major component of Turmeric (Curcuma longa) and extensive scientific research on curcumin and turmeric has demonstrated their potent antioxidant properties. Through their antioxidant mechanisms, curcumin and turmeric support colon health, exert neuroprotective activity and help maintain a healthy cardiovascular system.

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Curcumin Turmeric Supplement Facts:
Curcumin and Turmeric 500 mg *
Usage: Take 1 or 2 curcumin turmeric capsules a few times a week with breakfast, or as directed by your health consultant.
* Curcumin and Turmeric daily value not established

Health Benefit of Curcumin and Turmeric
Many human trials are needed before we can know with any certainty how we can best use curcumin in medicine. But one thing is certain: most doctors are not, at this time, aware of the potential benefits of curcumin and turmeric. You can buy Turmeric here.
   Other popular herbs and supplements with health benefits include mangosteen plant, Goji berry, noni fruit, and acai berry.

Curcumin and Alzheimer's disease
In laboratory studies, curcumin inhibits amyloid formation. Whether curcumin supplements help reduce the incidence of Alzheimer's disease or help improve this condition is not known at this time.

Curcumin and Cancer
The same research team that found curcumin interferes with melanoma cells also found curcumin helped stop the spread of breast cancer tumor cells to the lungs of mice. The curcumin suppressed two proteins that tumor cells use to keep themselves immortal. Studies evaluating the role of curcumin and cancer continue to advance at a fast rate.

Curcumin side effects
No apparent curcumin side effects have been reported in the medical literature thus far. Increased body temperature on high doses may be a possible curcumin side effect on high doses. A study performed at the University of Michigan showed no curcumin toxicity at doses up to 6 grams.
   Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006 Mar 17;6:10. Lao CD, Ruffin MT 4th, et al. University of Michigan, 2150 CCGC, Ann Arbor, MI.

Curcumin Turmeric Research update
Curcumin therapy in inflammatory bowel disease: a pilot study.
Dig Dis Sci. 2005 Nov;50(11):2191-3. Holt PR, Katz S, Kirshoff R.
St. Luke's Roosevelt Hospital Center, Columbia University and Strang Cancer Center Research Laboratory, New York, New York.
Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI ( crohn's disease activity index ) scores and sedimentation rates. This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies.

Turmeric, a yellow spice used widely in Indian cooking, stops the spread of cancer in mice. Curcumin, an active compound found in turmeric, helped stop the spread of breast cancer tumor cells to the lungs of mice. Tests have already started in people, too, said Bharat Aggarwal of the Department of Experimental Therapeutics at the University of Texas M.D. Anderson Cancer Center in Houston, who led the study. Earlier research showed that curcumin, an antioxidant, can help prevent tumors from forming in the laboratory. For their study, Aggarwal and colleagues injected mice with human breast cancer cells -- a batch of cells grown from a patient whose cancer had spread to the lungs. The resulting tumors were allowed to grow, and then surgically removed, to simulate a mastectomy, Aggarwal said. Then the mice either got no additional treatment; curcumin alone; the cancer drug paclitaxel, which is sold under the brand name Taxol; or curcumin plus Taxol. Half the mice in the curcumin -only group and 22 percent of those in the curcumin plus Taxol group had evidence of breast cancer that had spread to the lungs. But 75 percent of animals that got Taxol alone and 95 percent of those that got no treatment developed lung tumors. Earlier studies suggest that people who eat diets rich in turmeric have lower rates of breast cancer, prostate cancer, lung cancer and colon cancer. His team would like to try giving curcumin to women with a high risk of breast cancer -- such as those who have a mother or sister with the disease. No drug company is likely to develop a natural product that cannot be patented, he said. "There are no companies behind it so our only source of funding is either the National Institutes of Health or the Department of Defense," he said. This study was funded by the U.S. Department of Defense's Breast Cancer Research Program. Aggarwal's team is also testing curcumin against pancreatic cancer and multiple myeloma.

Curcumin content of turmeric and curry powders.
Nutr Cancer. 2006;55(2):126-31. Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Clinical Nutrition and Dietetics Department, Allied Health Sciences Faculty, The Hashemite University, Jordan.
Curcumin, derived from the rhizome curcuma longa, is one of the primary ingredients in turmeric and curry powders that are used as spices in Middle Eastern and Asian countries, especially on the Indian subcontinent. Whether the amount of curcumin in turmeric and curry powders is sufficient to suggest effects on biological activities and cancer risk is unknown. To determine and compare the quantitative amounts of curcumin that are present in several brands of turmeric and curry powders, a high performance liquid chromatography technique was used to analyze 28 spice products described as turmeric or curry powders and two negative controls. Pure turmeric powder had the highest curcumin concentration, averaging 3.14% by weight. The curry powder samples, with one exception, had relatively small amounts of curcumin present, and the variability in content was great. The curcumin content of these seasoning products that are consumed as a component of the diet should be considered in evaluating baseline tissue concentration and response to curcumin supplementation, which is under study in chemoprevention trials.

Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5.
Curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma burden in rodent models of colorectal cancer. We tested the hypothesis that pharmacologically active levels of curcumin can be achieved in the colorectum of humans. Patients with colorectal cancer ingested curcumin capsules (3,600, 1,800, or 450 mg daily) for 7 days. Biopsy samples of normal and malignant colorectal tissue, respectively, were obtained at diagnosis and at 6 to 7 hours after the last dose of curcumin. Blood was taken 1 hour after the last dose of curcumin. Curcumin and its metabolites were detected and quantitated by high-performance liquid chromatography with detection by UV spectrophotometry or mass spectrometry. The concentrations of curcumin in normal and malignant colorectal tissue of patients receiving 3,600 mg of curcumin were 12.7 +/- 5.7 and 7.7 +/- 1.8 nmol/g, respectively. Curcumin sulfate and curcumin glucuronide were identified in the tissue of these patients. Trace levels of curcumin were found in the peripheral circulation. The results suggest that a daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.

Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.
Clin Cancer Res. 2004 Oct 15;10(20):6847-54.
Curcumin, a polyphenolic antioxidant derived from a dietary spice, exhibits anticancer activity in rodents and in humans. Its efficacy appears to be related to induction of glutathione S-transferase enzymes, inhibition of prostaglandin E(2) (PGE(2)) production, or suppression of oxidative DNA adduct (M(1)G) formation. We designed a dose-escalation study to explore the pharmacology of curcumin in humans. Fifteen patients with advanced colorectal cancer refractory to standard chemotherapies consumed capsules compatible with curcumin doses between 0.45 and 3.6 g daily for up to 4 months. Levels of curcumin and its metabolites in plasma, urine, and feces were analyzed. Three biomarkers of the potential activity of curcumin were translated from preclinical models and measured in patient blood leukocytes: glutathione S-transferase activity, levels of M(1)G, and PGE(2) production induced ex vivo. Dose-limiting toxicity was not observed. Curcumin and its glucuronide and sulfate metabolites were detected in plasma in the 10 nmol/L range and in urine. A daily dose of 3.6 g curcumin engendered 62% and 57% decreases in inducible PGE(2) production in blood samples taken 1 hour after dose on days 1 and 29, respectively, of treatment compared with levels observed immediately predose. A daily oral dose of 3.6 g of curcumin is advocated for Phase II evaluation in the prevention or treatment of cancers outside the gastrointestinal tract. Levels of curcumin and its metabolites in the urine can be used to assess general compliance.

Turmeric, a spice used extensively in Asia as a key ingredient of curry, may be protecting children against leukemia. Curcumin inhibits the multiplication of leukemia cells in laboratory studies and seems to protect against damage caused by cigarette smoke and eating certain processed foods.

Curcumin modulates free radical quenching in myocardial ischaemia in rats.
Int J Biochem Cell Biol. 2004 Oct;36(10):1977-90.
This study was designed to investigate the protective effect of curcumin against isoprenaline induced myocardial ischaemia in rat myocardium. The effect of single oral dose of curcumin,, administered 30min before and/or after the onset of ischaemia, was investigated by assessing oxidative stress related biochemical parameters in rat myocardium. Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides and myeloperoxidase while the levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase activities were significantly increased after curcumin PPT. Histopathological and transmission electron microscopical studies also confirmed the severe myocardial damage occurring as a consequence of isoprenaline induced ischaemia and they also showed the significant improvement effected by curcumin. These findings provided evidence that curcumin was found to protect rat myocardium against ischaemic insult and the protective effect could be attributed to its antioxidant properties as well as its inhibitory effects on xanthine dehydrogenase/xanthine oxidase conversion and resultant superoxide anion production.

Curcumin turmeric Alzheimer's
Curcumin and turmeric are sometimes found together in products

Curcumin turmeric emails
Q. Is curcumin or turmeric capable of raising blood pressure?
   A. We have not seen any studies that would indicate curcumin or turmeric raise blood pressure.

Q. My father has primary amyloidosis and it has affected both his liver as well as the digestive system. Have you known of Tumeric and Curcumin to improve liver function. I respect the work that you do.
   A. Most of the time people taking curcumin and turmeric are taking other supplements. We have not tested liver health specifically after taking curcumin turmeric capsules by themselves.

Q. Which is better for health, curcumin turmeric supplement or bilberry lutein?
   A. All herbs have some benefit, you could alternate the two.

Q. I would like to know if curcumin turmeric supplements are affective in untreated leukemia in adults and children. Have you seen any research on the subject? I've read that curcumin turmeric are more affective if taken together with
piperine. Does your formula contain piperine? Also i'd like to know if you ship to Athens, Greece.
   A. Human studies are not available to determine if curcumin turmeric supplements are useful in the treatment of leukemia in adults or children. There is no research that says curcumin turmeric supplements are more effective if taken with piperine. Physician Formulas website ships to Athens, Greece.

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