Alpha lipoic acid, also known as
lipoic acid is a powerful,
natural antioxidant slowly becoming recognized as having benefit in the
therapy and prevention of a broad range of diseases. In addition to being a
powerful antioxidant,
alpha lipoic acid benefits the body in the use of glucose, hence alpha lipoic acid's potential role in improving
blood sugar control. Alpha lipoic acid reduces complications from a high sugar diet. Lipoic acid is readily absorbed from the diet or as a supplement.
Alpha lipoic Acid has a variety of
benefits, particularly for diabetics.
R Alpha Lipoic Acid product 50 mg
capsule, 90 Tablets -
Ray Sahelian, M.D.
Physician
Formulas uses the highest quality R-Alpha Lipoic Acid. R-ALA is much
more potent (2 times on average) than commonly sold synthetic lipoic acid
which contains both the R and S forms of lipoic acid. The S form is
chemically the mirror image of the R form of lipoic acid and is not useful
to the body.
R Alpha Lipoic Acid Supplement Facts
R Alpha Lipoic Acid capsule - 50 mg *
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The two types of Alpha Lipoic acid
If you're taking a conventional
lipoic acid supplement, you're likely
only getting half or less of the benefit of natural lipoic acid. The reason for
this is that most alpha lipoic acid products on the market have both forms of
lipoic acid: the synthetic S form, and the natural R form.
R-Lipoic
acid is much more potent (2 times on average) than commonly sold synthetic
lipoic acid which contains both the R and S forms of lipoic acid. The S form is
chemically the mirror image of the R form of lipoic acid and cannot be used
by the body, hence it is useless. Thus, 50 mg of R-Lipoic Acid is equivalent to
100 mg of synthetic lipoic acid.
Animal research has shown that R alpha lipic acid acid can more
efficiently than other forms of lipoic acid increase or maintain levels of other
antioxidants including COQ 10, vitamin C, vitamin E and glutathione, which often
declines with age.
Dosage of Alpha Lipoic Acid
As we found out recently about vitamin E, high doses of antioxidant
supplements may not lead to more benefits. In fact, there
comes a point where a supplement, no matter how benign, can become unhealthy if
the doses are too high. For this reason I do not recommend more than 10 to 50
mg of alpha lipoic a day. There are products out there that have 300 mg of alpha lipoic per capsule. I am not convinced they are healthy to take,
except perhaps to treat an existing medical condition for a specific period of
time.
Alpha
Lipoic Acid benefit as an
Antioxidant
Lipoic acid can regenerate vitamin C from its oxidized form, dehydroascorbic acid.
Lipoic acid can also potentially regenerate other antioxidants. Lipoic acid increases the
levels of glutathione, a very important antioxidant normally found in our cells and
responsible for mopping up all types of toxins and free radicals. Glutathione supplements,
however, are not helpful since glutathione does not have the ability to cross cell
membranes. Fortunately, both laboratory and animal studies have shown that alpha lipoic acid can
stimulate the production of this antioxidant. This is particularly important during
periods of excessive stress or exposure to radiation or toxic substances. Lipoic acid also acts as a powerful antioxidant in the brain and is likely to
protect brain cells from toxins.
Alpha Lipoic acid benefit
for medical conditions
Research in humans with lipoic acid is still incomplete. However, alpha
lipoic may
theoretically be worthwhile to explore in a variety of medical conditions, including diabetes, heart
disease, hypertension, high cholesterol, Alzheimer's disease, Parkinson's
disease, and Huntington's disease.
Alpha Lipoic Acid
Side Effects
There are no indications that low doses of lipoic acid, such as 5 to 20 mg, have side
effects. Higher doses could cause nausea or stomach upset, along with over-stimulation, fatigue, and insomnia. High doses could also potentially lower
blood sugar. This is often beneficial to patients who have diabetes, but it
requires close monitoring of blood sugar levels. We have had one report of 300
mg of alpha lipoic acid taken 3 times a day for three weeks led to atrial
fibrillation. Another person emailed that a 50 mg dose of R lipoic acid made him
feel his heart racing, he took it at the same time as his thyroid medication
Levothyroid. Those with thyroid problems may consider taking half a capsule of a
50 mg R alpha lipoic acid dose.
Summary
Until long-term studies with alpha lipoic acid are published on humans regarding
alpha lipoic acid benefit and risks, we do not recommend that
you take more than 10 to 50 mg a day unless you’re being treated for a
particular condition under medical supervision. Since alpha lipoic acid helps restore antioxidants, you may need less
vitamins C and E and other antioxidants when you take them along with alpha lipoic
acid.
Alpha Lipoic acid benefit for
Diabetes
Lipoic acid is helpful in diabetes,
particularly for those with diabetic
neuropathy and diabetic nephropathy. Oxidative stress plays a central role in the
cause and progression of late microangiopathic (small vessel) complications in
diabetes mellitus. Treatment of diabetic patients with the antioxidant lipoic
acid reduce oxidative stress and urinary albumin excretion, and slows the
progression of endothelial cell damage. Alpha lipoic acid may also may tissues
more sensitive to insulin.
Diabetics are prone to
kidney disease and oxidative stress may play a major role in the progression of
diabetic kidney disease. Previous studies have suggested that treatment of
diabetic patients with the antioxidant alpha-lipoic acid reduces oxidative
stress and urinary protein excretion. In this study completed at the University
of Heidelberg in Germany, the effect of alpha lipoic acid on the progression of
kidney cell damage and the course of diabetic nephropathy was evaluated in 84
patients with diabetes over 18 months. Forty-nine patients had no antioxidant
treatment and served as a control group. Thirty-five patients were treated with
600 mg alpha-lipoic acid per day. After 18 months of follow up, those on lipoic
acid had a slower progression of the disease than the control group as shown by
a decrease in the amount of protein lost in urine. Previous studies have shown
that alpha lipoic acid may be helpful for diabetic neuropathy, the loss of sensation
often first noticed in feet. Laboratory studies have also indicated that lipoic
acid reverses the age-associated decline in the proper functioning of
mitochondria. Mitochondria are enclosures located within each cell. They are
primarily responsible for energy production.
Alpha
Lipoic acid benefit for Diabetic Neuropathy
High blood sugar levels for prolonged periods can be toxic to nerves in the body.
Diabetics who don't control their blood sugar eventually start losing sensation in their
feet. Other problems follow resulting from damage to various nerves that supply internal
organs. Even impotence can result due to loss of nerve sensation in genital organs.
However high blood sugar may not be the only culprit. Diabetics are usually under high
oxidative stress and this probably contributes to their neurological problems.
Several studies indicate that alpha lipoic acid has
beneficial effects on diabetic neuropathy, party due to its actions as an antioxidant, and
also by improving the circulation to tiny blood vessels supplying nerve tissue.
Alpha Lipoic Acid
benefit for Memory
Feeding lipoic acid and acetyl-l-carnitine to old rats improves performance on
memory tasks by lowering oxidative damage and improving mitochondrial function.
Alpha Lipoic acid benefit for Burning Mouth Syndrome
Burning mouth syndrome (BMS) has features of a neuropathy and
could be related to the production of the toxic free radicals that are released in stress
situations. Alpha-lipoic acid is an antioxidant able to increase the levels of
intracellular glutathione and eliminate free radicals. This study aimed to examine the
effectiveness of alpha-lipoic acid in the therapy of BMS. Method: This was a double blind, controlled
study conducted for two months on 60 patients with constant BMS. Comparing alpha-lipoic
acid (test) with cellulose starch (placebo).
Results and Conclusions: Following
treatment with alpha lipoic acid, there was a significant symptomatic improvement, compared with
placebo, with the majority showing at least some improvement after 2 months, thus
supporting the hypothesis that burning mouth syndrome is a neuropathy. This improvement
was maintained in over 70% of patients at the 1 year follow-up.
Loss of Smell (Olfactory)
Alpha Lipoic acid may help regenerate loss of smell after a cold.
Alpha Lipoic acid benefit for retinal
pigment cells
R alpha lipoic acid protects retinal pigment epithelial cells
from oxidative damage.
Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4302-10.
Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS.
Biophysics Graduate Group, University of California, Berkeley, USA.
To determine whether R alpha lipoic acid protects cultured human fetal
retinal pigment epithelial (hfRPE) cells against oxidative injury and identify
the pathways that may mediate protection. Cultured hfRPE cells were pretreated
with various concentrations of R alpha lipoic acid for 14 to 16 hours followed
by treatment with a chemical oxidant, tert-butylhydroperoxide. Reactive oxygen
species (ROS) production and cell viability were measured. RESULTS: Pretreatment
of hfRPE cells with R alpha lipoic acid significantly reduced the levels of t-BuOOH-induced
intracellular ROS, by 23% and 49%, respectively. R alpha lipoic acid prevented
oxidant-induced cell death and apoptosis and also increased the viability of
oxidant-treated hfRPE cells from 38% to 90% of control. The present
study suggests that the protective effect of R alpha lipoic acid involves
multiple pathways and that R alpha lipoic acid could be effective against
age-associated increase in oxidative stress and mitochondrial dysfunction in RPE
cells.
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